Lithium is a prescription mood stabilizer. A 2021 analysis of online psychedelic experience reports found 62 reports involving lithium, of which 47% described seizures and 39% described seeking medical attention, while 34 reports involving lamotrigine described no seizures (Nayak et al., 2021). The authors called their conclusion provisional.
Most of those reports involved LSD. A 2022 systematic review summarized the psilocybin-only reports as 2 of 6 with seizures and rated the evidence low quality (Sarparast et al., 2022), and a 2024 review of drug interactions also mentions lithium-related seizures with LSD or psilocybin (Halman et al., 2024).
Self-reports cannot show how often this happens or why. Trials do not fill the gap, because they usually exclude people with a history of bipolar disorder, as one 2021 depression trial did (Davis et al., 2021). Nobody can say the combination is safe, and medication decisions belong with a prescriber. This is not medical advice.
General information, not medical advice. In an emergency in Canada, call 911. For a mental-health crisis, call or text 9-8-8.
Sources
- Nayak et al. (2021), Classic psychedelic coadministration with lithium, but not lamotrigine, is associated with seizures
- Sarparast et al. (2022), Drug-drug interactions between psychiatric medications and MDMA or psilocybin
- Halman et al. (2024), Drug-drug interactions involving classic psychedelics
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