Health Canada says that using magic mushrooms with substances such as cannabis, amphetamines or alcohol raises the risk of serious side effects and adverse events (Health Canada). Among 19 people in a large online survey who sought emergency treatment after mushrooms, 37% had used cannabis and 32% alcohol before the incident (Kopra et al., 2022).
US poison-centre data show the same pattern: of 6,933 psilocybin-related encounters from 2013 to 2022, 31.8% involved at least one other drug (Montoy et al., 2025). A 2026 analysis of mushroom edibles linked polysubstance exposure to hospital admission and more severe toxicity (Jorgenson et al., 2026). In a prospective survey of 321 people, more concurrent cannabis went with more intense experiences (Kuc et al., 2022).
Specific medicine combinations have their own reported dangers, including seizures with lithium and hypertensive or serotonergic reactions with MAO inhibitors. Nobody can say any combination is safe. This entry describes risk only and is not medical advice.
General information, not medical advice. In an emergency in Canada, call 911. For a mental-health crisis, call or text 9-8-8.
Sources
- Health Canada: Psilocybin and psilocin (magic mushrooms)
- Kopra et al. (2022), Adverse experiences resulting in emergency medical treatment seeking
- Montoy et al. (2025), US poison center encounters for psilocybin-related exposures
- Jorgenson et al. (2026), Psychoactive mushroom edibles: trends and toxicities
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